Supporting your memory

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Gefinancierd op 20 / 05 / 2023
Gecofinancierd!
Ontvangen
$ 4,935
Minimum
$ 3,288
Optimum
$ 9,863
78 Co-financiers
Channel
  • Bijdragen $ 11

    Acknowledgement and mention in Social Networks

    Acknowledgement on our Facebook page, Twitter, etc.

    > 07 Co-financiers
  • Bijdragen $ 16

    Acknowledgement + exclusive digital microscope images

    Acknowledgement on our Facebook page, Twitter, etc.
    Emailing of exclusive images obtained with a digital microscope.

    > 09 Co-financiers
  • Bijdragen $ 32

    Acknowledgement + digital images + virtual laboratory visit

    Acknowledgement on our Facebook page, Twitter, etc.
    Emailing of exclusive images obtained with a digital microscope.
    Emailing of a virtual tour of our research facilities.

    > 02 Co-financiers
  • Bijdragen $ 43

    Acknowledgement + digital images + book

    Acknowledgement on our Facebook page, Twitter, etc.
    Sending by email of exclusive images obtained with a digital microscope.
    Mailing of the book "Gimnasia para Estimular tu Cerebro: Entrenena tu Mente" (Gymnastics to Stimulate your Brain: Train your Mind).

    > 11 Co-financiers
  • Bijdragen $ 49

    Agradecimiento + imágenes digitales + libro2
    • Agradecimiento a la persona en nuestra página de Facebook, Twitter, etc.

    • Envío por correo electrónico de imágenes exclusivas obtenidas con un microscopio digital.

    • Envío por correo postal del libro "Arrugas" (autor: Paco Roca).


    ¡Tu participación puede desgravarse!
    Aportando 45 €, puedes desgravarte hasta un 80% de tu donación.
    Calcúlalo: https://www.goteo.org/calculadora-fiscal

    > 02 Co-financiers
  • Bijdragen $ 54

    Sponsor a lab experiment

    Acknowledgement on our Facebook page, Twitter, etc.
    The donor will be able to sponsor a laboratory experiment.

    > 04 Co-financiers
  • Bijdragen $ 81

    Acknowledgment + book + sponsor a lab experiment

    Acknowledgment on our Facebook page, Twitter, etc.
    The donor will be able to sponsor a laboratory experiemnt.
    Mailing of the book "Gimnasia para Estimular tu Cerebro: Entrenena tu Mente" (Gymnastics to Stimulate your Brain: Train your Mind).

    > 02 Co-financiers
  • Bijdragen $ 108

    Acknowledgement + digital images + book + guided tour of the laboratory

    Acknowledgement on our Facebook page, Twitter, etc.
    Sending by email of exclusive images obtained with a digital microscope.
    Mailing of the book "Gimnasia para Estimular tu Cerebro: Entrenena tu Mente" (Gymnastics to Stimulate your Brain: Train your Mind).
    Visit to our work center and research laboratory where we will explain what techniques we use and our daily work.

    > 04 Co-financiers
  • Bijdragen $ 216

    Complete package with virtual lab visit

    Acknowledgment on our Facebook page, Twitter, etc.
    Sending by email of exclusive images obtained with a digital microscope.
    Mailing of the book "Gimnasia para Estimular tu Cerebro: Entrenena tu Mente" (Gymnastics to Stimulate your Brain: Train your Mind).
    Sending by e-mail of a virtual visit to our research laboratory.
    The donor will be able to sponsor a laboratory experiment.

    > 01 Co-financiers
  • Bijdragen $ 540

    Complete package with guided laboratory visit

    Acknowledgment on our Facebook page, Twitter, etc.
    Sending by email of exclusive images obtained with a digital microscope.
    Mailing of the book "Gimnasia para Estimular tu Cerebro: Entrenena tu Mente" (Gymnastics to Stimulate your Brain: Train your Mind).
    The donor will be able to sponsor a laboratory experiment.
    Visit to our work center and research laboratory where we will explain the techniques we use and our daily work.

    > 00 Co-financiers
  • Bijdragen $ 1,081

    Full sponsorship

    The person or entity will appear in all events where the project is presented. A special mention will be made in scientific articles and conference presentations, as well as the logo of the collaborating company will be shown in presentations and lectures. You will receive a guided visit to our laboratory and the above rewards.

    > 00 Co-financiers

About this project

Biomarkers of Interferon type I response in patients with neurological diseases.

Behoeften Materiaal Minimum Optimum
Specific laboratory supplies
Purchase of test kits (ELISA bioplex-SIMOA) for the detection of biomarkers in the blood of 40 patients.
$ 2,162
Basic laboratory supplies
Purchase of reagents and basic consumables for blood processing of 40 patients.
$ 540
Specific laboratory supplies
Purchase of test kits (ELISA bioplex-SIMOA) for the detection of biomarkers in the blood of 80 patients.
$ 4,323
Basic laboratory supplies
Purchase of reagents and basic consumables for blood processing of 80 patients.
$ 1,081
Behoeften Infrastructuur Minimum Optimum
Use of facilities and equipment
Access to facilities and use of equipment for biomarker analysis (plate 1).
$ 108
Use of facilities and equipment
Access to facilities and use of equipment for biomarker analysis (plates 1 & 2).
$ 216
Behoeften Taak Minimum Optimum
Commissions 10%
Commissions to Universidad de Málaga, Goteo 5%, TPV 0,8% y PayPal 3,4% + 0,35 cents/transaction.
$ 478
Commissions 10%
Commissions to Universidad de Málaga, Goteo 5%, TPV 0,8% y PayPal 3,4% + 0,35 cents/transaction.
$ 955
Totaal $ 3,288 $ 9,863
Noodzakelijk
Additioneel

General information

Neurological disorders are the third most common cause of disability and premature death in the EU, and increase with the aging of our population. In fact, in Spain it is estimated that they may affect some 7 million Spaniards. These disorders are diseases of the central and peripheral nervous system, i.e. the brain, spinal cord, cranial and peripheral nerves, autonomic nervous system, nerve roots, neuromuscular plates and muscles. There are more than 600 neurological diseases, with neurodegenerative diseases such as Multiple Sclerosis, Alzheimer's disease and Parkinson's disease being the most important.

Many of the causes of neurodegenerative diseases are unknown and available medical tests may only be useful in assessing the state of an already affected nervous system. The prognosis of neurodegenerative diseases can be quite serious, among other reasons because there is no way to prevent them and their treatments are ineffective as they are limited to palliating the symptoms and not curing the patient. Therefore, in neurodegenerative diseases, it is of vital importance to establish an early, rapid or predictive diagnosis to control a more favorable evolution and establish the most appropriate personalized treatment.

Our research group has been working on the search for inflammatory biomarkers that allow us to identify the main diseases with neurological involvement (Alzheimer's disease, Parkinson's disease, dementia, addictions, etc.). These biomarkers can be used for early detection of the disease, diagnosis, evaluation of its activity or monitoring the efficacy of its treatments. Recent findings show that type β-interferon (IFN-β) responses are a central element in neuroinflammation associated with neurological disorders, but at the same time are critical for neuronal function. Thus, type I interferon and its activity in the brain are potential targets in the investigation of new biomarkers for these pathologies, obtaining a clear clinical benefit.

Belangrijkste kenmerken

Our objective is to identify biomarkers for early diagnosis of diseases such as Alzheimer's, Parkinson's, dementia and cognitive impairment, since they do not exist. For this purpose, we have collections of serum samples from these patients, and their associated clinical data, from the Hospital Regional Universitario de Málaga and the Biobank of Málaga-IBIMA-SSPA. The project includes the publication of the results, their communication and dissemination, as well as their clinical-analytical validation. Finally, clinical practice guidelines will be developed in collaboration with the clinical team of the Hospital.
The project will be developed in 4 milestones:

  1. Recruitment of patients from the Neurology Department of the Hospital Regional Universitario de Málaga.
  2. Collect blood samples and obtain the plasmas.
  3. Measure inflammatory biomarkers with ELISA bioplex and SIMOA technology.
  4. Create a panel of markers that predict the disease.
  5. Communication and dissemination of results to society.

Waarom is dit belangrijk

Neurodegenerative diseases, which affect the nervous system and cause memory loss, behavioral disorders and cognitive functions, are increasing worldwide as life expectancy increases. Currently, the World Health Organization estimates that there are more than 30 million patients in the world with Alzheimer's disease, with this figure doubling every five years.
This project is motivated by the need to advance in research on neurodegenerative diseases and in the constant search for tools that help early detection of the degenerative process and prevent the loss of cognitive functions (memory and learning).

This project is aimed at patients with neurodegenerative diseases (Multiple Sclerosis, Alzheimer, Parkinson) and their relatives, patient associations, professionals in care centers (hospitals and health centers), scientific community in neurology and mental health, academic community in health sciences, and the general population with higher life expectancy, susceptible to suffer with higher probability of a mental deterioration associated with age.

Team en ervaring

The research group is a consolidated group of the Biomedical Research Institute of Malaga (IBIMA), formed by a multidisciplinary team (physicians, nurses, psychologists, biologists and biochemists) belonging to the Faculty of Medicine of the University of Malaga and to the Clinical Units of Neurology and Mental Health of the University Regional Hospital of Malaga. The team has a solid track record of more than 25 years backed by very outstanding scientific contributions in the field of neuroscience and mental health.

https://www.ibima.eu/grupo_investigacion/neuropsicofarmacologia/

Social commitment

Sustainable Development Goals

  • Good Health and Well-Being

    Ensuring healthy lives and promoting the well-being for all at all ages is essential to sustainable development.

  • Industry, Innovation and Infrastructure

    Investments in infrastructure are crucial to achieving sustainable development.

  • Reduced Inequalities

    To reduce inequalities, policies should be universal in principle, paying attention to the needs of disadvantaged and marginalized populations.